RPK1 phosphorylation and cell death

ABSTRACT: The molecular mechanisms regulating the switch between RIPK1 pro-survival and pro-death functions remain poorly understood. We identified Ikkα/β-mediated phosphorylation of RIPK1 as a key mechanism inhibiting RIPK1 kinase activity and preventing TNF-mediated RIPK1 kinase-dependent cell death.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture, Embryonic Stem Cell

SUBMITTER: Piero Giansanti  

LAB HEAD: Albert J.R. Heck

PROVIDER: PXD009857 | Pride | 2019-04-02

REPOSITORIES: Pride