Proteomics

Dataset Information

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RIME against TRPS1 in breast cancer cell lines

ABSTRACT: Identification of TRPS1 interactors in MCF7, T47D and ZR75-1 breast cancer cell lines.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Brain Cancer

SUBMITTER: Aurelien Serandour  

LAB HEAD: Jason Carroll

PROVIDER: PXD009863 | Pride | 2018-06-12

REPOSITORIES: Pride

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Publications

TRPS1 regulates oestrogen receptor binding and histone acetylation at enhancers.

Serandour A A AA   Mohammed H H   Miremadi A A   Mulder K W KW   Carroll J S JS  

Oncogene 20180612 39

The chromatin state is finely tuned to regulate function and specificity for transcription factors such as oestrogen receptor alpha (ER), which contributes to cell growth in breast cancer. ER transcriptional potential is mediated, in large part, by the specific associated proteins and co-factors that interact with it. Despite the identification and characterisation of several ER coregulators, a complete and systematic view of ER-regulating chromatin modifiers is lacking. By exploiting a focused  ...[more]