Target identification of SB2001 by thermal proteome profiling

ABSTRACT: In this study, we identified target proteins of SB2001, a cytotoxic agent that acts specifically against HeLa cells. Because SB2001 (= A08) lacked of chemical modification sites, label-free target identification methods using the thermal proteome profiling (TPP) were applied to characterize its mechanism of action. SB2024 (= A11) was used as a negative control compound.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Cervix Carcinoma

SUBMITTER: Hankum Park  

LAB HEAD: Seung Bum Park

PROVIDER: PXD009903 | Pride | 2019-11-04

REPOSITORIES: Pride