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Insulin Granule and Secreted Peptidome

ABSTRACT: Insulin peptidome, for dense core granules, crinosomes and secretome, was characterized by nLC-MS/MS.

OTHER RELATED OMICS DATASETS IN: GSE114824

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Urine, Islet Of Langerhans, Pancreas

DISEASE(S): Disease Free

SUBMITTER: Cheryl Lichti

LAB HEAD: Emil R. Unanue

PROVIDER: PXD009919 | Pride | 2018-07-23

REPOSITORIES: Pride

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Publications

Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides.

Wan Xiaoxiao X Zinselmeyer Bernd H BH Zakharov Pavel N PN Vomund Anthony N AN Taniguchi Ruth R Santambrogio Laura L Anderson Mark S MS Lichti Cheryl F CF Unanue Emil R ER

Nature 20180718 7716

Tissue-specific autoimmunity occurs when selected antigens presented by susceptible alleles of the major histocompatibility complex are recognized by T cells. However, the reason why certain specific self-antigens dominate the response and are indispensable for triggering autoreactivity is unclear. Spontaneous presentation of insulin is essential for initiating autoimmune type 1 diabetes in non-obese diabetic mice<sup>1,2</sup>. A major set of pathogenic CD4 T cells specifically recognizes the 1 ...[more]

PMID: 30022165

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