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Influenza A virus induced proteome changes

ABSTRACT: Seasonal epidemics of influenza A virus in the human population are a major cause of severe illness and are of high socio-economic relevance. For the design of effective anti-viral therapies, a detailed knowledge of cellular pathways perturbed by virus infection is critical. We performed comprehensive expression and organellar proteomics experiments using A549, Calu-1 and NCI-H1299 cells to identify new protein targets and cellular pathways affected by influenza A virus.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human) Influenza A Virus (a/aichi/68/2007(h3n2))

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Influenza

SUBMITTER: Joern Dengjel

LAB HEAD: Joern Dengjel

PROVIDER: PXD009924 | Pride | 2018-07-12

REPOSITORIES: Pride

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Influenza A Virus Induces Autophagosomal Targeting of Ribosomal Proteins.

Becker Andrea C AC Gannagé Monique M Giese Sebastian S Hu Zehan Z Abou-Eid Shadi S Roubaty Carole C Paul Petra P Bühler Lea L Gretzmeier Christine C Dumit Veronica I VI Kaeser-Pebernard Stéphanie S Schwemmle Martin M Münz Christian C Dengjel Jörn J

Molecular & cellular proteomics : MCP 20180706 10

Seasonal epidemics of influenza A virus are a major cause of severe illness and are of high socio-economic relevance. For the design of effective antiviral therapies, a detailed knowledge of pathways perturbed by virus infection is critical. We performed comprehensive expression and organellar proteomics experiments to study the cellular consequences of influenza A virus infection using three human epithelial cell lines derived from human lung carcinomas: A549, Calu-1 and NCI-H1299. As a common ...[more]

PMID: 29980615

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