Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Monocyte, Chest Muscle
DISEASE(S): Inflammation
SUBMITTER: Christian Preisinger
LAB HEAD: Frank Tacke
PROVIDER: PXD009944 | Pride | 2019-01-24
REPOSITORIES: Pride
Heymann Felix F von Trotha Klaus-Thilo KT Preisinger Christian C Lynen-Jansen Petra P Roeth Anjali A AA Geiger Melanie M Geisler Lukas Jonathan LJ Frank Anna Katharina AK Conze Joachim J Luedde Tom T Trautwein Christian C Binnebösel Marcel M Neumann Ulf P UP Tacke Frank F
JCI insight 20190124 2
Polypropylene meshes that are commonly used for inguinal hernia repair may trigger granulomatous foreign body reactions. Here, we show that asymptomatic patients display mesh-associated inflammatory granulomas long after surgery, which are dominated by monocyte-derived macrophages expressing high levels of inflammatory activation markers. In mice, mesh implantation by the onlay technique induced rapid and strong myeloid cell accumulation, without substantial attenuation for up to 90 days. Myeloi ...[more]