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Combined proteomic and functional analysis reveals rich sources of protein diversity in skin mucus and venom from Scorpaena plumieri fish

ABSTRACT: This study shed light on the protein profile of the venomous extract and the skin mucus from S. plumieri, potentially contributing with fundamental information for future basic research, and even – through a better understanding of venomous fish toxinology – aiding in the search for new clinical strategies to treat the envenomation. Finally, seeing as fish venoms remain considerably less studied when compared to terrestrial venoms, the exploration of their full potential opens a myriad of possibilities for the development of new drugs and for a deeper understanding of complex physiological processes.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Scorpaena Plumieri

SUBMITTER: Marcia Borges

LAB HEAD: Márcia Helena Borges

PROVIDER: PXD009983 | Pride | 2018-08-15

REPOSITORIES: Pride

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Combined proteomic and functional analysis reveals rich sources of protein diversity in skin mucus and venom from the Scorpaena plumieri fish.

Borges Márcia H MH Andrich Filipe F Lemos Pedro H PH Soares Thiago G TG Menezes Thiago N TN Campos Fabiana V FV Neves Leandro X LX Castro-Borges William W Figueiredo Suely G SG

Journal of proteomics 20180808

The biological activities observed upon envenomation by Scorpaena plumieri could be linked to both the venom and the skin mucus. Through a proteomic/functional approach we analyzed protein composition and biological activities of the venom and skin mucus. We identified 885 proteins: 722 in the Venomous Apparatus extracts (Sp-VAe) and 391 in the Skin Mucus extract (Sp-SMe), with 494 found exclusively in Sp-VAe, being named S. plumieri Venom Proteins (Sp-VP), while 228 were found in both extracts. ...[more]

PMID: 30098406

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