KIF1A, TANC2, liprin-a2 interactomes identified by AP-MS.
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite, Q Exactive
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Brain
SUBMITTER: 
Riccardo Stucchi
LAB HEAD: Casper Hoogenraad
PROVIDER: PXD010080 | Pride | 2018-07-12
REPOSITORIES: Pride
Publications
Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca<sup>2+</sup>/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites.
Stucchi Riccardo R Plucińska Gabriela G Hummel Jessica J A JJA Zahavi Eitan E EE Guerra San Juan Irune I Klykov Oleg O Scheltema Richard A RA Altelaar A F Maarten AFM Hoogenraad Casper C CC
Cell reports 20180701 3
Tight regulation of neuronal transport allows for cargo binding and release at specific cellular locations. The mechanisms by which motor proteins are loaded on vesicles and how cargoes are captured at appropriate sites remain unclear. To better understand how KIF1A-driven dense core vesicle (DCV) transport is regulated, we identified the KIF1A interactome and focused on three binding partners, the calcium binding protein calmodulin (CaM) and two synaptic scaffolding proteins: liprin-α and TANC2 ...[more]
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