Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
SUBMITTER: Yong Zhang
LAB HEAD: Lianwen Zhang
PROVIDER: PXD010173 | Pride | 2019-09-16
REPOSITORIES: Pride
Liu Li L Li Ling L Ma Cheng C Shi Yangde Y Liu Congcong C Xiao Zikang Z Zhang Yong Y Tian Fang F Gao Yang Y Zhang Jie J Ying Wantao W Wang Peng George PG Zhang Lianwen L
The Journal of biological chemistry 20190916 45
<i>O</i>-GlcNAcylation is a ubiquitous protein glycosylation playing different roles on variant proteins. <i>O</i>-GlcNAc transferase (OGT) is the unique enzyme responsible for the sugar addition to nucleocytoplasmic proteins. Recently, multiple <i>O</i>-GlcNAc sites have been observed on short-form OGT (sOGT) and nucleocytoplasmic OGT (ncOGT), both of which locate in the nucleus and cytoplasm in cell. Moreover, <i>O</i>-GlcNAcylation of Ser<sup>389</sup> in ncOGT (1036 amino acids) affects its ...[more]