Proteomics

Dataset Information

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Fish Liver Immune Response LC-MSMS


ABSTRACT: High-throughput proteomics was used to determine the role of the fish liver in defense responses to bacterial infection, done using a rainbow trout (Oncorhynchus mykiss) model following infection with Aeromonas salmonicida, the causative agent of furunculosis. The vertebrate liver has multifaceted roles in innate immunity, metabolism, and growth; we hypothesize this tissue serves a dual function in supporting host defense in parallel to metabolic adjustments that promote effective immune function. While past studies have reported mRNA responses to A. salmonicida in salmonids, the impact of bacterial infectionon the liver proteome remains uncharacterized in fish.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Oncorhynchus Mykiss (rainbow Trout) (salmo Gairdneri)

TISSUE(S): Liver

SUBMITTER: Dwight Causey  

LAB HEAD: Daniel Macqueen

PROVIDER: PXD010186 | Pride | 2018-10-08

REPOSITORIES: Pride

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Publications

High-throughput proteomic profiling of the fish liver following bacterial infection.

Causey Dwight R DR   Pohl Moritz A N MAN   Stead David A DA   Martin Samuel A M SAM   Secombes Christopher J CJ   Macqueen Daniel J DJ  

BMC genomics 20181001 1


<h4>Background</h4>High-throughput proteomics was used to determine the role of the fish liver in defense responses to bacterial infection. This was done using a rainbow trout (Oncorhynchus mykiss) model following infection with Aeromonas salmonicida, the causative agent of furunculosis. The vertebrate liver has multifaceted functions in innate immunity, metabolism, and growth; we hypothesize this tissue serves a dual role in supporting host defense in parallel to metabolic adjustments that prom  ...[more]

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