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Db/db - Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia

ABSTRACT: the phosphoproteomic landscape of beta-cell adaptive flexibility after exposure to glucose

INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Pancreatic Islet, Pancreas

DISEASE(S): Obesity,Type 2 Diabetes Mellitus

SUBMITTER: Taewook Kang

LAB HEAD: Taewook Kang

PROVIDER: PXD010265 | Pride | 2019-07-22

REPOSITORIES: Pride

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Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia.

Kang Taewook T Boland Brandon B BB Alarcon Cristina C Grimsby Joseph S JS Rhodes Christopher J CJ Larsen Martin R MR

Journal of proteome research 20190731 9

For the treatment of patients with prediabetes or diabetes, clinical evidence has emerged that β-cell function can be restored by glucose-lowering therapeutic strategies. However, little is known about the molecular mechanisms underlying this functional adaptive behavior of the pancreatic β-cell. This study examines the dynamic changes in protein expression and phosphorylation state associated with (pro)insulin production and secretory pathway function mediated by euglycemia to induce β-cell res ...[more]

PMID: 31317746

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