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Identification of ZNF217 interactors in MCF7 breast cancer cell line

ABSTRACT: Identification of TRPS1 interactors in MCF7 breast cancer cell line.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Breast Cancer

SUBMITTER: Aurelien Serandour

LAB HEAD: Jason Carroll

PROVIDER: PXD010312 | Pride | 2018-07-17

REPOSITORIES: Pride

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TRPS1 regulates oestrogen receptor binding and histone acetylation at enhancers.

Serandour A A AA Mohammed H H Miremadi A A Mulder K W KW Carroll J S JS

Oncogene 20180612 39

The chromatin state is finely tuned to regulate function and specificity for transcription factors such as oestrogen receptor alpha (ER), which contributes to cell growth in breast cancer. ER transcriptional potential is mediated, in large part, by the specific associated proteins and co-factors that interact with it. Despite the identification and characterisation of several ER coregulators, a complete and systematic view of ER-regulating chromatin modifiers is lacking. By exploiting a focused ...[more]

PMID: 29895970

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