Chd4 controls Ripk3 dependent necroptosis during muscle regeneration

ABSTRACT: We performed a label-free LC-MS/MS study to analyse the role of Chd4 regulation in MuSC in suppressing genes enabling programmed cell death as part of the muscle regeneration program. Lox-cre recombination was used to create a deletion mutant of the CHD4 chromatin modifier (exons 12-21). A pseudo "infection" with GFP was used as control. Proteomics analysis here serves as a method to compare the differentially deregulated proteins upon knockdown of Chd4 in MuSCs using Adenoviral CRE recombination.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Muscle Stem Cell

SUBMITTER: Carsten Kuenne  

LAB HEAD: Marcus Krüger

PROVIDER: PXD010370 | Pride | 2020-04-02

REPOSITORIES: Pride