Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Epithelial Ovarian Cancer Cell
DISEASE(S): Malignant Neoplasm Of Ovary
SUBMITTER: Mario Oroshi
LAB HEAD: Matthias Mann
PROVIDER: PXD010372 | Pride | 2020-04-19
REPOSITORIES: Pride
Coscia Fabian F Lengyel Ernst E Duraiswamy Jaikumar J Ashcroft Bradley B Bassani-Sternberg Michal M Wierer Michael M Johnson Alyssa A Wroblewski Kristen K Montag Anthony A Yamada S Diane SD López-Méndez Blanca B Nilsson Jakob J Mund Andreas A Mann Matthias M Curtis Marion M
Cell 20180901 1
Most high-grade serous ovarian cancer (HGSOC) patients develop resistance to platinum-based chemotherapy and recur, but 15% remain disease free over a decade. To discover drivers of long-term survival, we quantitatively analyzed the proteomes of platinum-resistant and -sensitive HGSOC patients from minute amounts of formalin-fixed, paraffin-embedded tumors. This revealed cancer/testis antigen 45 (CT45) as an independent prognostic factor associated with a doubling of disease-free survival in adv ...[more]