Dataset Information

Platelet proteome is affected by cancer presence and therapy

ABSTRACT: Platelets play an important role in primary hemostasis, inflammation , (tumor) angiogenesis and cancer metastasis. Platelets are produced by megakaryocytes in the bone marrow and contain numerous bioactive proteins (e.g. growth factors, chemokine’s and proteases). These proteins inside platelets are either synthesized by the parental megakaryocytes or absorbed from the (micro)circulation. Therefore, it was postulated that changes in platelet protein content might indicate the presence or recurrence of a malignant tumor. We followed up the notion that both cancer and cancer therapy affect the platelet proteome. The aim of the current study was 1) to identify a pan-cancer proteome signature that could be used to discriminate patients with cancer from healthy individuals, and 2) to investigate the effect of cancer therapy on the platelet proteome. In this study, we included patients with cancer and healthy controls. Using global protein profiling by mass spectrometry-based proteomics we determined that the platelet proteome is affected by both cancer presence and antitumor therapy.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Platelet

DISEASE(S): Rectum Cancer,Anus Cancer,Colon Cancer,Tongue Squamous Cell Carcinoma,Stomach Carcinoma

SUBMITTER: Sander Piersma

LAB HEAD: Connie Ramona Jimenez

PROVIDER: PXD010380 | Pride | 2021-09-08

REPOSITORIES: Pride

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Publications

Effects of Cancer Presence and Therapy on the Platelet Proteome.

Walraven Maudy M Sabrkhany Siamack S Knol Jaco C JC Dekker Henk H de Reus Inge I Piersma Sander R SR Pham Thang V TV Griffioen Arjan W AW Broxterman Henk J HJ Oude Egbrink Mirjam M Verheul Henk M W HMW Jimenez Connie R CR

International journal of molecular sciences 20210730 15

Platelets are involved in tumor angiogenesis and cancer progression. Previous studies indicated that cancer could affect platelet content. In the current study, we investigated whether cancer-associated proteins can be discerned in the platelets of cancer patients, and whether antitumor treatment may affect the platelet proteome. Platelets were isolated from nine patients with different cancer types and ten healthy volunteers. From three patients, platelets were isolated before and after the sta ...[more]

PMID: 34361002

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Dataset Information

Platelet proteome is affected by cancer presence and therapy

Publications

Effects of Cancer Presence and Therapy on the Platelet Proteome.

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