Proteomics

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Quantitative proteomes of Imp2 KO mouse 2-cell-stage embryos

ABSTRACT: Data showing the late 2-cell-stage, control embryos (Imp2♀+/♂+) and Imp2-knockout embryos (Imp2♀−/♂+) for HPLC MS/MS analysis. 3 replicates were performed using 330 embryos per group.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Embryo

SUBMITTER: hao zhang  

LAB HEAD: Xuejiang Guo

PROVIDER: PXD010397 | Pride | 2019-11-12

REPOSITORIES: Pride

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Publications

RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation.

Liu Hong-Bin HB   Muhammad Tahir T   Guo Yueshuai Y   Li Meng-Jing MJ   Sha Qian-Qian QQ   Zhang Chuan-Xin CX   Liu Hui H   Zhao Shi-Gang SG   Zhao Han H   Zhang Hao H   Du Yan-Zhi YZ   Sun Kang K   Liu Kui K   Lu Gang G   Guo Xue-Jiang XJ   Sha Jiahao J   Fan Heng-Yu HY   Gao Fei F   Chen Zi-Jiang ZJ  

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20190524 15

A number of genes involved in zygotic genome activation (ZGA) have been identified, but the RNA-binding maternal factors that are directly related to ZGA in mice remain unclear. The present study shows that maternal deletion of <i>Igf  2bp2</i> (also commonly known as <i>Imp2</i>) in mouse embryos causes early embryonic developmental arrest in vitro at the 2-cell-stage. Transcriptomics and proteomics analyses of 2-cell-stage embryos in mice reveal that deletion of IMP2 downregulates the expressi  ...[more]

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