Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Stromal Cell
DISEASE(S): Chronic Lymphocytic Leukemia
SUBMITTER: James Williamson
LAB HEAD: Ingo Ringshausen
PROVIDER: PXD010401 | Pride | 2018-09-19
REPOSITORIES: Pride
Mangolini Maurizio M Götte Frederik F Moore Andrew A Ammon Tim T Oelsner Madlen M Lutzny-Geier Gloria G Klein-Hitpass Ludger L Williamson James C JC Lehner Paul J PJ Dürig Jan J Möllmann Michael M Rásó-Barnett Lívia L Hughes Katherine K Santoro Antonella A Méndez-Ferrer Simón S Oostendorp Robert A J RAJ Zimber-Strobl Ursula U Peschel Christian C Hodson Daniel J DJ Schmidt-Supprian Marc M Ringshausen Ingo I
Nature communications 20180921 1
The Wnt signalling pathway, one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL), is activated in only a subset of patients through somatic mutations. Here we describe alternative, microenvironment-dependent mechanisms of Wnt activation in malignant B cells. We show that tumour cells specifically induce Notch2 activity in mesenchymal stromal cells (MSCs) required for the transcription of the complement factor C1q. MSC-derived C1q in turn inhibits Gsk3-β mediated degradati ...[more]