Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung
DISEASE(S): Lung Squamous Cell Carcinoma
SUBMITTER: John Koomen
LAB HEAD: Eric Haura, MD
PROVIDER: PXD010429 | Pride | 2019-05-24
REPOSITORIES: Pride
Stewart Paul A PA Welsh Eric A EA Slebos Robbert J C RJC Fang Bin B Izumi Victoria V Chambers Matthew M Zhang Guolin G Cen Ling L Pettersson Fredrik F Zhang Yonghong Y Chen Zhihua Z Cheng Chia-Ho CH Thapa Ram R Thompson Zachary Z Fellows Katherine M KM Francis Jewel M JM Saller James J JJ Mesa Tania T Zhang Chaomei C Yoder Sean S DeNicola Gina M GM Beg Amer A AA Boyle Theresa A TA Teer Jamie K JK Ann Chen Yian Y Koomen John M JM Eschrich Steven A SA Haura Eric B EB
Nature communications 20190808 1
How genomic and transcriptomic alterations affect the functional proteome in lung cancer is not fully understood. Here, we integrate DNA copy number, somatic mutations, RNA-sequencing, and expression proteomics in a cohort of 108 squamous cell lung cancer (SCC) patients. We identify three proteomic subtypes, two of which (Inflamed, Redox) comprise 87% of tumors. The Inflamed subtype is enriched with neutrophils, B-cells, and monocytes and expresses more PD-1. Redox tumours are enriched for oxida ...[more]