Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Skin, Endothelium
DISEASE(S): Cardiovascular System Disease
SUBMITTER: Roman Fischer
LAB HEAD: Roman Fischer
PROVIDER: PXD010430 | Pride | 2018-10-02
REPOSITORIES: Pride
Bailey Jade J Davis Simon S Shaw Andrew A Diotallevi Marina M Fischer Roman R Benson Matthew A MA Zhu Hanneng H Brown James J Bhattacharya Shoumo S Kessler Benedikt M BM Channon Keith M KM Crabtree Mark J MJ
Scientific reports 20180925 1
Nitric Oxide (NO) is an intracellular signalling mediator, which affects many biological processes via the posttranslational modification of proteins through S-nitrosation. The availability of NO and NOS-derived reactive oxygen species (ROS) from enzymatic uncoupling are determined by the NO synthase cofactor Tetrahydrobiopterin (BH4). Here, using a global proteomics "biotin-switch" approach, we identified components of the ubiquitin-proteasome system to be altered via BH4-dependent NO signallin ...[more]