Mucin-binding proteins of E. coli membrane
Ontology highlight
ABSTRACT:
INSTRUMENT(S): maXis
ORGANISM(S): Escherichia Coli
SUBMITTER: 
Daria Rakitina
LAB HEAD: Gleb Yurievich Fisunov
PROVIDER: PXD010472 | Pride | 2019-12-16
REPOSITORIES: Pride
Publications
Mucin adsorbed by E. coli can affect neutrophil activation in vitro.
Mikhalchik Elena E Balabushevich Nadezhda N Vakhrusheva Tatiana T Sokolov Alexey A Baykova Julia J Rakitina Daria D Scherbakov Petr P Gusev Sergey S Gusev Alexander A Kharaeva Zaira Z Bukato Olga O Pobeguts Olga O
FEBS open bio 20191219 2
Bacteria colonizing human intestine adhere to the gut mucosa and avoid the innate immune system. We previously demonstrated that Escherichia coli isolates can adsorb mucin from a diluted solution in vitro. Here, we evaluated the effect of mucin adsorption by E. coli cells on neutrophil activation in vitro. Activation was evaluated based on the detection of reactive oxygen species production by a chemiluminescent reaction (ChL), observation of morphological alterations in neutrophils and detectio ...[more]
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