Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion ETD
ORGANISM(S): Middle East Respiratory Syndrome-related Coronavirus Severe Acute Respiratory Syndrome-related Coronavirus
SUBMITTER: Joost Snijder
LAB HEAD: David Veesler
PROVIDER: PXD010494 | Pride | 2019-05-01
REPOSITORIES: Pride
Cell 20190131 5
Recent outbreaks of severe acute respiratory syndrome and Middle East respiratory syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the importance of finding ways to combat these viruses. The trimeric spike transmembrane glycoprotein S mediates entry into host cells and is the major target of neutralizing antibodies. To understand the humoral immune response elicited upon natural infections with coronaviruses, we structurally characterized the SARS-CoV and MER ...[more]