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Data in support of proteomics of EVs ámd mimetic vesicles from

ABSTRACT: Exosomes (EXOs) are a biological subset of extracellular vesicles of 50-200 nm in size which are released by most cells upon fusion of multivehicular bodies with plasma membrane.Mimetic-Nanovesicles (M-NVs) have higher yield compare to exosomes. In addition, M-NVs can untangle the difficulties associated with the isolation and purification of cell culture exosomes. M-NVs is consist of membranouslipid bilayer which could be derived from extrusion of cells through filter membrane. Several studies have used M-NVs for therapeutic delivery of genetic materials and drug. The proteomic content of these vesicles with regard to protein identities and post-translational modifications remain uncharacterized and proteomic data is presented in this dataset.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Obesity

SUBMITTER: Allan Stensballe

LAB HEAD: Allan Stensballe

PROVIDER: PXD010539 | Pride | 2022-01-05

REPOSITORIES: Pride

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Proteomic and Post-Translational Modification Profiling of Exosome-Mimetic Nanovesicles Compared to Exosomes.

Nasiri Kenari Amirmohammad A Kastaniegaard Kenneth K Greening David W DW Shambrook Mitch M Stensballe Allan A Cheng Lesley L Hill Andrew F AF

Proteomics 20190403 8

Issues associated with upscaling exosome production for therapeutic use may be overcome through utilizing artificial exosomes. Cell-derived mimetic nanovesicles (M-NVs) are a potentially promising alternative to exosomes for clinical applicability, demonstrating higher yield without incumbent production and isolation issues. Although several studies have shown that M-NVs have similar morphology, size and therapeutic potential compared to exosomes, comprehensive characterization and to what exten ...[more]

PMID: 30790448

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