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Immunomic identification of antigens

ABSTRACT: Immunomic screening of mice immune sera with different protection efficiencies against the whole P. yoelii 17X parasite proteome was performed to identify the repertoire of antigens recognized by those sera. The calculation of weighted scores reflecting the likelihood of protection of each antigens using five predictive criteria derived from immunomic and proteomic datasets, highlighted a priority list of protective antigens.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Plasmodium Yoelii 17x

TISSUE(S): Erythrocyte, Blood

DISEASE(S): Malaria

SUBMITTER: Anthony Siau

LAB HEAD: Anthony Siau

PROVIDER: PXD010567 | Pride | 2019-02-15

REPOSITORIES: Pride

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Immunomic Identification of Malaria Antigens Associated With Protection in Mice.

Siau Anthony A Huang Ximei X Loh Han Ping HP Zhang Neng N Meng Wei W Sze Siu Kwan SK Renia Laurent L Preiser Peter P

Molecular & cellular proteomics : MCP 20190204 5

Efforts to develop vaccines against malaria represent a major research target. The observations that 1) sterile protection can be obtained when the host is exposed to live parasites and 2) the immunity against blood stage parasite is principally mediated by protective antibodies suggest that a protective vaccine is feasible. However, only a small number of proteins have been investigated so far and most of the <i>Plasmodium</i> proteome has yet to be explored. To date, only few immunodominant an ...[more]

PMID: 30718293

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