293FT Cell Endogenous FANCA Protein-Protein Interactions

ABSTRACT: Hyperinsulinemia affects 72% of Fanconi anemia (FA) patients and an additional 25% experience lowered glucose tolerance or frank diabetes. The underlying molecular mechanisms contributing to the dysfunction of FA pancreas β cells is unknown. These experiments were performed in 293FT HEK cells as a part of the optimization and validation of the endogenous IP and to establish the FANCA interactome in a non-pancreas cell line to delineate beta cell-specific FANCA interactions.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Early Embryonic Cell

DISEASE(S): Fanconi Anemia Complementation Group A

SUBMITTER: Nicholas Woods  

LAB HEAD: Nicholas T. Woods, Ph.D.

PROVIDER: PXD010570 | Pride | 2019-07-25

REPOSITORIES: Pride