Quantitative Microproteomics Based Characterization of the Central and Peripheral Nervous System of a Mouse Model of Krabbe Disease

ABSTRACT: In-depth characterization of the proteome of the Twitcher mouse, a mouse model for Krabbe disease, to investigate the proteome changes in the Central and Peripheral Nervous System.We applied a TMT-based workflow to compare the proteomes of the corpus callosum, motor cortex and sciatic nerves of littermate Twitcher and wild-type mice.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain, Sciatic Nerve

DISEASE(S): Krabbe Disease

SUBMITTER: Davide Pellegrini  

LAB HEAD: Liam A. McDonnell

PROVIDER: PXD010594 | Pride | 2019-04-04

REPOSITORIES: Pride