Ontology highlight
ABSTRACT:
INSTRUMENT(S): maXis
ORGANISM(S): Zea Mays (maize)
SUBMITTER: Fatih Demir
LAB HEAD: Pitter Florian Huesgen
PROVIDER: PXD010596 | Pride | 2019-02-25
REPOSITORIES: Pride
Misas Villamil Johana C JC Mueller André N AN Demir Fatih F Meyer Ute U Ökmen Bilal B Schulze Hüynck Jan J Breuer Marlen M Dauben Helen H Win Joe J Huesgen Pitter F PF Doehlemann Gunther G
Nature communications 20190405 1
Ustilago maydis is a biotrophic fungus causing corn smut disease in maize. The secreted effector protein Pit2 is an inhibitor of papain-like cysteine proteases (PLCPs) essential for virulence. Pit2 inhibitory function relies on a conserved 14 amino acids motif (PID14). Here we show that synthetic PID14 peptides act more efficiently as PLCP inhibitors than the full-length Pit2 effector. Mass spectrometry shows processing of Pit2 by maize PLCPs, which releases an inhibitory core motif from the PID ...[more]