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Glutathione S-transferase induction after exposure to benzo[a]pyrene

ABSTRACT: Benzo[a]pyrene induction of glutathione S-transferases, an activity-based protein profiling investigation

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Matthew Monroe

LAB HEAD: Aaron Wright

PROVIDER: PXD010610 | Pride | 2020-05-26

REPOSITORIES: Pride

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Benzo[ a]pyrene Induction of Glutathione S-Transferases: An Activity-Based Protein Profiling Investigation.

Stoddard Ethan G EG Killinger Bryan J BJ Nag Subhasree A SA Martin Jude J Corley Richard R Smith Jordan N JN Wright Aaron T AT

Chemical research in toxicology 20190412 6

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants generated from combustion of carbon-based matter. Upon ingestion, these molecules can be bioactivated by cytochrome P450 monooxygenases to oxidized toxic metabolites. Some of these metabolites are potent carcinogens that can form irreversible adducts with DNA and other biological macromolecules. Conjugative enzymes, such as glutathione S-transferases or UDP-glucuronosyltransferases, are responsible for the detoxifi ...[more]

PMID: 30938511

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