Proteomics

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Necator americanus secretome - In the current project we have carried out the first proteogenomic analysis of a parasitic helminth

ABSTRACT: In the current project we have carried out the first proteogenomic analysis of a parasitic helminth. This has allowed us to significantly improve the genome annotation and provide a robust characterisation of the ES proteome from the adult N. americanus. Our findings show important information on key families of proteins with both known and unknown functions which may be instrumental for host-parasite interactions, parasite survival and immune regulation. Description of these proteins is useful for informing future identification of vaccine and drug targets, diagnostics and novel therapeutics for treating autoimmune and allergic diseases.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Necator Americanus

SUBMITTER: Javier Sotillo  

LAB HEAD: Alex Loukas

PROVIDER: PXD010669 | Pride | 2019-09-26

REPOSITORIES: Pride

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The human hookworm Necator americanus infects more than 400 million people worldwide, contributing substantially to the poverty in these regions. Adult stage N. americanus live in the small intestine of the human host where they inject excretory/secretory (ES) products into the mucosa. ES products have been characterized at the proteome level for a number of animal hookworm species, but until now, the difficulty in obtaining sufficient live N. americanus has been an obstacle in characterizing th  ...[more]

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