Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: F Butter
LAB HEAD: Falk Butter
PROVIDER: PXD010672 | Pride | 2018-12-17
REPOSITORIES: Pride
Bluhm Alina A Viceconte Nikenza N Li Fudong F Rane Grishma G Ritz Sandra S Wang Suman S Levin Michal M Shi Yunyu Y Kappei Dennis D Butter Falk F
Nucleic acids research 20190201 4
Telomeres are nucleoprotein structures at the ends of linear chromosomes and present an essential feature for genome integrity. Vertebrate telomeres usually consist of hexameric TTAGGG repeats, however, in cells that use the alternative lengthening of telomeres (ALT) mechanism, variant repeat sequences are interspersed throughout telomeres. Previously, it was shown that NR2C/F transcription factors bind to TCAGGG variant repeats and contribute to telomere maintenance in ALT cells. While specific ...[more]