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Autophagy the key player in trabecular meshwork death-mechanistic difference in early and advanced glaucoma

ABSTRACT: This study highlights the differential roles of apoptosis versus autophagy in cell death mechanism in the trabecular meshwork in primary adult glaucoma at various stages. This reflects the possible role of autophagy in causing glaucomatous damage in severe disease stages

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Eye, Eye Trabecular Meshwork

DISEASE(S): Glaucoma

SUBMITTER: gagan jhingan

LAB HEAD: Aparna Rao

PROVIDER: PXD010752 | Pride | 2021-09-08

REPOSITORIES: Pride

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Switch to Autophagy the Key Mechanism for Trabecular Meshwork Death in Severe Glaucoma.

Rao Aparna A Sahay Prity P Chakraborty Munmun M Prusty Birendra Kumar BK Srinivasan Sandhya S Jhingan Gagan Deep GD Mishra Pragyan P Modak Rahul R Suar Mrutyunjay M

Clinical ophthalmology (Auckland, N.Z.) 20210714

<h4>Purpose</h4>The key differences in cell death mechanisms in the trabecular meshwork (TM) in adult moderate and severe primary glaucoma remain still unanswered. This study explored key differences in cell death mechanisms in the trabecular meshwork (TM) in adult moderate and severe primary glaucoma.<h4>Design</h4>In-vitro laboratory study on surgical specimens and primary cell lines.<h4>Methods</h4>Select cell death-related proteins differentially expressed on mass spectrometric analysis in e ...[more]

PMID: 34285469

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