Proteomics study of THP-1 monocytic cells exposed to surface modified-gold nanoparticles
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Monocyte
SUBMITTER: 
Jimmy Ytterberg
LAB HEAD: Roman A. Zubarev
PROVIDER: PXD010858 | Pride | 2019-03-18
REPOSITORIES: Pride
Publications
Cationic gold nanoparticles elicit mitochondrial dysfunction: a multi-omics study.
Gallud Audrey A Klöditz Katharina K Ytterberg Jimmy J Östberg Nataliya N Katayama Shintaro S Skoog Tiina T Gogvadze Vladimir V Chen Yu-Zen YZ Xue Ding D Moya Sergio S Ruiz Jaime J Astruc Didier D Zubarev Roman R Kere Juha J Fadeel Bengt B
Scientific reports 20190313 1
Systems biology is increasingly being applied in nanosafety research for observing and predicting the biological perturbations inflicted by exposure to nanoparticles (NPs). In the present study, we used a combined transcriptomics and proteomics approach to assess the responses of human monocytic cells to Au-NPs of two different sizes with three different surface functional groups, i.e., alkyl ammonium bromide, alkyl sodium carboxylate, or poly(ethylene glycol) (PEG)-terminated Au-NPs. Cytotoxici ...[more]
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