Proteomics

Dataset Information

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PLASMA biomarkers of Idiopathic Pulmonary Fibrosis


ABSTRACT: The aim of the current study is to find plasma-based biomarker candidates for Idiopathic Pulmonary Fibrosis (IPF). Incidence of IPF seems to be increasing in Europe and there is significant mortality associated with IPF. There are no sensistive biomarkers for IPF and diagnosis is entirely clinical and/or histopathological which is often delayed. Minimally invasive biomarkers of IPF would be expected to aid clinicians perfrom early diagnosis of IPF enabling better management of the disease.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma, Blood

SUBMITTER: Sakari Joenväärä  

LAB HEAD: Risto Renkonen

PROVIDER: PXD010965 | Pride | 2020-05-13

REPOSITORIES: Pride

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Publications

Label-free plasma proteomics identifies haptoglobin-related protein as candidate marker of idiopathic pulmonary fibrosis and dysregulation of complement and oxidative pathways.

Saraswat Mayank M   Joenväärä Sakari S   Tohmola Tiialotta T   Sutinen Eva E   Vartiainen Ville V   Koli Katri K   Myllärniemi Marjukka M   Renkonen Risto R  

Scientific reports 20200508 1


Idiopathic pulmonary fibrosis (IPF) is a lung parenchymal disease of unknown cause usually occurring in older adults. It is a chronic and progressive condition with poor prognosis and diagnosis is largely clinical. Currently, there exist few biomarkers that can predict patient outcome or response to therapies. Together with lack of markers, the need for novel markers for the detection and monitoring of IPF, is paramount. We have performed label-free plasma proteomics of thirty six individuals, 1  ...[more]

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