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Hair Proteome Variation at Different Body Locations on GVP Detection for Protein-Based Human Identification

ABSTRACT: Characterization of body location-specific hair proteomic variation and its effect on the identification of genetically variant peptide markers for protein-based human identification. LLNL-MI-756827

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Keratinocyte

SUBMITTER: Fanny Chu

LAB HEAD: Bradley R. Hart

PROVIDER: PXD010982 | Pride | 2019-05-22

REPOSITORIES: Pride

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Hair Proteome Variation at Different Body Locations on Genetically Variant Peptide Detection for Protein-Based Human Identification.

Chu Fanny F Mason Katelyn E KE Anex Deon S DS Jones A Daniel AD Hart Bradley R BR

Scientific reports 20190521 1

Human hair contains minimal intact nuclear DNA for human identification in forensic and archaeological applications. In contrast, proteins offer a pathway to exploit hair evidence for human identification owing to their persistence, abundance, and derivation from DNA. Individualizing single nucleotide polymorphisms (SNPs) are often conserved as single amino acid polymorphisms in genetically variant peptides (GVPs). Detection of GVP markers in the hair proteome via high-resolution tandem mass spe ...[more]

PMID: 31113963

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