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Mycobacterium tuberculosis H37Rv treated with VC or not

ABSTRACT: The global protein expression of Mycobacterium tuberculosis H37Rv, responding to VC treatment (5 mM for 24 h), was monitored via tandem mass tag (TMT)-based quantitative proteomic analysis.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mycobacterium Tuberculosis H37rv

TISSUE(S): Cell Culture

SUBMITTER: Jin Wang

LAB HEAD: Jin Wang

PROVIDER: PXD010984 | Pride | 2018-12-19

REPOSITORIES: Pride

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Publications

Pharmacologic ascorbate as a pro-drug for hydrogen peroxide release to kill mycobacteria.

Pei Zenglin Z Wu Kang K Li Zehuan Z Li Chaoqun C Zeng Ling L Li Feng F Pei Ning N Liu Hongmei H Zhang Shu-Lin SL Song Yan-Zheng YZ Zhang Xiaoyan X Xu Jianqing J Fan Xiao-Yong XY Wang Jin J

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20181127

<h4>Background and purpose</h4>Tuberculosis is one of the most highly fatal diseases worldwide, and one-third of the world's population has been infected with Mycobacterium tuberculosis (M. tuberculosis). A previous study showed that M. tuberculosis was highly susceptible to being killed by ascorbate (i.e. vitamin C, VC), but the molecular mechanisms of the bactericidal activity of VC against M. tuberculosis are still not well understood.<h4>Experimental approach</h4>We assayed the effects of VC ...[more]

PMID: 30551469

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