Proteomics

Dataset Information

2

Real-time molecular diagnosis of tumors using water-assisted laser desorption/ionization mass spectrometry technology


ABSTRACT: This dataset contains MS imaging raw data as well as the SCiLS file used to confirm the regions in dog sarcoma biopsies classified by the SpiderMass system after analysis of the consecutive tissue section. All the tissues were gathered during dog sarcoma surgeries, snap-frozen and analysed later in the lab. The images were acquired on a MALDI LTQ orbitrap XL hybrid instrument.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Canis lupus familiaris  

TISSUE(S): Spleen, Gastrointestinal Tract, Mesenchymal Epithelium, Lung, Subcutaneous Tissue, Skin, Chorion, Bone

DISEASE(S): Sarcoma

SUBMITTER: Jusal Quanico  

LAB HEAD: Michel Salzet

PROVIDER: PXD010990 | Pride | 2019-04-12

REPOSITORIES: pride

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Publications


Histopathological diagnosis of biopsy samples and margin assessment of surgical specimens are challenging aspects in sarcoma. Using dog patient tissues, we assessed the performance of a recently developed technology for fast ex vivo molecular lipid-based diagnosis of sarcomas. The instrument is based on mass spectrometry (MS) molecular analysis through a laser microprobe operating under ambient conditions using excitation of endogenous water molecules. Classification models based on cancer/norma  ...[more]

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