Protein kinase C-beta regulates environment mediated drug resistance in B cell malignancies

ABSTRACT: Environment-mediated drug resistance (EMDR) limits the efficacy of cancer therapies by providing anti-apoptotic signals from a non-malignant microenvironment to tumour cells. We show that EMDR is regulated by protein kinase C in stromal cells is required for EMDR. We used plasma membrane profiling to demonstrate that PKC-beta regulates numerous plasma membrane proteins required for cell-cell communications and EMDR.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Stromal Cell

DISEASE(S): Chronic Lymphocytic Leukemia

SUBMITTER: James Williamson  

LAB HEAD: Ingo Ringshuasen

PROVIDER: PXD011062 | Pride | 2021-09-08

REPOSITORIES: Pride