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Sequential modulation of RNase III and RNase G expression in response to host environment conditions promotes pathogenicity through the control of hns expression in Salmonella Typhimurium

ABSTRACT: Our results demonstrate that RNase G controls expression levels of H-NS encoded by hns, strongly associated with the pathogenicity of S. Typhimurium. The hns mRNA abundance is mediated by RNase G, which cleaves the 5’-UTR of hns mRNA. In the upstream pathway, the induced expression of RNase G in host environment condition is attributable to reduced RNase III cleavage activity on rng mRNA. Our findings suggest the link between Salmonella pathogenicity and RNase III-RNase G pathway, underlining the importance of posttranscriptional regulation of H-NS in the downstream pathway, which controls Salmonella pathogenicity island-1 type III secretion system for the survival and virulence of S. Typhimurium in host cell.

INSTRUMENT(S): ProteomeDiscoverer input parameter

ORGANISM(S): Salmonella Enterica Subsp. Enterica Serovar Typhimurium Str. Sl1344

TISSUE(S): Cell Line Cell

DISEASE(S): Salmonellosis

SUBMITTER: Yong-Hak Kim

LAB HEAD: Yong-Hak Kim

PROVIDER: PXD011090 | Pride | 2021-01-08

REPOSITORIES: Pride

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