Repression of Human Papillomavirus Oncogene Expression under Hypoxia is Mediated by PI3K/mTORC2/AKT Signaling

ABSTRACT: Cornerstones of the regulatory phenomena observed in hypoxic HPV-positive cancer cells are: (i) hypoxia blocks E6/E7, an effect that can be counteracted by (ii) AKT inhibition and by (iii) high glucose supply. To gain further insights into the underlying regulatory circuits, mass spectrometry-based quantitative proteome analyses were performed comparing normoxic and hypoxic SiHa cells and assessing their response towards AKTi VIII and 25 mM glucose under hypoxia

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Cervix Carcinoma

SUBMITTER: Bianca Kuhn  

LAB HEAD: Felix Hoppe-Seyler

PROVIDER: PXD011095 | Pride | 2019-02-18

REPOSITORIES: Pride