Proteomic characterization of a hyper-virulent isolate of Pseudomonas aeruginosa

ABSTRACT: Taxonomic outliers of Pseudomonas aeruginosa recently emerged as infectious for humans. Here we present the first analysis of a hyper-virulent isolate that cause hemorrhagic pneumonia. We demonstrated that, in two sequential clones CLJ1 and CLJ3 recovered from a patient with chronic obstructive pulmonary disease undergoing antibiotic therapy, insertion of a mobile genetic element into the P. aeruginosa chromosome affected major virulence-associated phenotypes and led to increased resistance to antibiotics used to treat the patient. Our work reveals insertion sequences as major players in enhancing the pathogenic potential of a P. aeruginosa taxonomic outlier by modulating both the virulence and resistance to antimicrobials. This also explains the ability of this bacterium to adapt to an infected host and cause a serious disease.

INSTRUMENT(S):

ORGANISM(S): Pseudomonas Aeruginosa

SUBMITTER: Yohann Couté  

LAB HEAD: Virginie Brun

PROVIDER: PXD011105 | Pride | 2019-03-18

REPOSITORIES: Pride