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Schistosoma haematobium proteomes

ABSTRACT: Despite the clear role of adult secreted and tegumental proteins as well as egg proteins in host-parasite interactions, there has not been any in-depth proteomic analysis of these or other Schistosoma haematobium proteomes. In the current project we have carried out the first comprehensive proteomic analysis of S. haematobium. The characterisation of the molecules playing a key role at the interphase between the host and the parasite is crucial for (i) a better understanding of the parasite’s biology and, (ii) for the development of new control and diagnostic approaches to tackle parasitic infections.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Schistosoma Haematobium

SUBMITTER: Javier Sotillo

LAB HEAD: Alex Loukas

PROVIDER: PXD011137 | Pride | 2019-04-09

REPOSITORIES: Pride

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In-depth proteomic characterization of Schistosoma haematobium: Towards the development of new tools for elimination.

Sotillo Javier J Pearson Mark S MS Becker Luke L Mekonnen Gebeyaw G GG Amoah Abena S AS van Dam Govert G Corstjens Paul L A M PLAM Murray Janice J Mduluza Takafira T Mutapi Francisca F Loukas Alex A

PLoS neglected tropical diseases 20190515 5

<h4>Background</h4>Schistosomiasis is a neglected disease affecting hundreds of millions worldwide. Of the three main species affecting humans, Schistosoma haematobium is the most common, and is the leading cause of urogenital schistosomiasis. S. haematobium infection can cause different urogenital clinical complications, particularly in the bladder, and furthermore, this parasite has been strongly linked with squamous cell carcinoma. A comprehensive analysis of the molecular composition of its ...[more]

PMID: 31091291

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