Proteomics

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Comparative analysis of Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes


ABSTRACT: Salmonella enterica subsp. enterica contains more than 2,600 serovars of which four are of major medical relevance for humans. While the typhoidal serovars (Typhi and Paratyphi A) are human-restricted and cause enteric fever, non-typhoidal Salmonella serovars (Typhimurium and Enteritidis) have a broad host range and predominantly cause gastroenteritis. In this study, we compared the core proteomes of Salmonella Typhi, Paratyphi A, Typhimurium and Enteritidis using contemporary proteomics. Five isolates, covering different geographical origins, and one reference strain per serovar were grown in vitro to the exponential phase. Protein levels of orthologous proteins between serovars were compared and subjected to gene ontology term enrichment and inferred regulatory interactions. Differential expression of the core proteomes of the typhoidal serovars appears mainly related to cell surface components and, for the non-typhoidal serovars, to pathogenicity. Our findings may guide future development of novel diagnostics and vaccines, and understanding of disease progression.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150   Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S   Salmonella enterica subsp. enterica serovar Typhi str. CT18   Salmonella enterica subsp. enterica serovar Enteritidis str. P125109  

TISSUE(S): Cell Culture

DISEASE(S): Not Available

SUBMITTER: Sara Saleh  

LAB HEAD: Stijn Deborggraeve

PROVIDER: PXD011154 | Pride | 2019-05-13

REPOSITORIES: Pride

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Publications

Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes reveal differentially expressed proteins linked to the cell surface and pathogenicity.

Saleh Sara S   Van Puyvelde Sandra S   Staes An A   Timmerman Evy E   Barbé Barbara B   Jacobs Jan J   Gevaert Kris K   Deborggraeve Stijn S  

PLoS neglected tropical diseases 20190524 5


BACKGROUND:Salmonella enterica subsp. enterica contains more than 2,600 serovars of which four are of major medical relevance for humans. While the typhoidal serovars (Typhi and Paratyphi A) are human-restricted and cause enteric fever, non-typhoidal Salmonella serovars (Typhimurium and Enteritidis) have a broad host range and predominantly cause gastroenteritis. METHODOLOGY/PRINCIPLE FINDINGS:We compared the core proteomes of Salmonella Typhi, Paratyphi A, Typhimurium and Enteritidis using cont  ...[more]

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