Dataset Information

Quantitative analysis of proteome dynamics in a long-term asthma mouse model

ABSTRACT: Asthma bronchiale is an inflammatory disease of the respiratory airways and a major factor of increasing health care costs worldwide. The molecular actors leading to asthma are not fully understood and require further investigation. The aim of this study was to monitor the proteome during asthma development from early inflammatory to late fibrotic stages. A time-course-based ovalbumin (OVA) mouse model was applied to establish an asthma phenotype and the lung proteome was analysed at four time points during asthma development (0 weeks = control, 5 weeks, 8 weeks and 12 weeks of OVA treatment).

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lung

DISEASE(S): Asthma

SUBMITTER: Thilo Bracht

LAB HEAD: Barbara Sitek

PROVIDER: PXD011159 | Pride | 2021-02-11

REPOSITORIES: Pride

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Publications

Quantitative analysis of proteome dynamics in a mouse model of asthma.

Funke Lukas L Gnipp Stefanie S Ahrens Maike M Eisenacher Martin M Peters Marcus M Sitek Barbara B Bracht Thilo T

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20210215 11

<h4>Background</h4>Asthma is an inflammatory disease of the respiratory system, and a major factor of increasing health care costs worldwide. The molecular actors leading to the development of chronic asthma are not fully understood and require further investigation.<h4>Objective</h4>The aim of this study was to monitor the proteome dynamics during asthma development from early inflammatory to late fibrotic stages.<h4>Methods</h4>A mouse asthma model was used to analyse the lung proteome at four ...[more]

PMID: 33550702

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Dataset Information

Quantitative analysis of proteome dynamics in a long-term asthma mouse model

Publications

Quantitative analysis of proteome dynamics in a mouse model of asthma.

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