Dataset Information

Rat atria-2D LC-MS/MS - Atrial electrophysiological and molecular remodelling induced by obstructive sleep apnoea

ABSTRACT: To understand the molecular change occurring in the atria during obstructive sleep apnea, we have implemented a rat model of OSA involving the surgical implantation of a tracheal obstructive device, allowing the rats to remain conscious and free-roaming throughout 2 weeks of apnea administration. Rats were divided into severe and moderate apnea groups, receiving a 23 second or 13 second apneas per minute, respectively. The two-dimensional polyacrylamide gel electrophoresis (2D PAGE) of atrial homogenates to compare the dysregulations in the protein pattern in severe and moderate apnea when compared to control.

INSTRUMENT(S): Xevo G2 Q-Tof

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Heart

SUBMITTER: Devika Channaveerappa

LAB HEAD: Costel C. Darie

PROVIDER: PXD011181 | Pride | 2019-02-21

REPOSITORIES: Pride

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Atrial electrophysiological and molecular remodelling induced by obstructive sleep apnoea.

Channaveerappa Devika D Lux Jacob C JC Wormwood Kelly L KL Heintz Timothy A TA McLerie Meredith M Treat Jacqueline A JA King Hannah H Alnasser Donia D Goodrow Robert J RJ Ballard Glenn G Decker Robert R Darie Costel C CC Panama Brian K BK

Journal of cellular and molecular medicine 20170412 9

Obstructive sleep apnoea (OSA) affects 9-24% of the adult population. OSA is associated with atrial disease, including atrial enlargement, fibrosis and arrhythmias. Despite the link between OSA and cardiac disease, the molecular changes in the heart which occur with OSA remain elusive. To study OSA-induced cardiac changes, we utilized a recently developed rat model which closely recapitulates the characteristics of OSA. Male Sprague Dawley rats, aged 50-70 days, received surgically implanted tra ...[more]

PMID: 28402037

Publication: 1/2

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Dataset Information

Rat atria-2D LC-MS/MS - Atrial electrophysiological and molecular remodelling induced by obstructive sleep apnoea

Publications

Atrial electrophysiological and molecular remodelling induced by obstructive sleep apnoea.

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