VDAC2 promotes BAX apoptotic activity

ABSTRACT: Intrinsic apoptosis is critical for normal physiology including the prevention of tumor formation. BAX and BAK, which are essential for mediating this process and for the cytotoxic action of many anti-cancer drugs, are thought to be regulated through similar mechanisms and act redundantly to drive apoptosis. Here we have established the various mitochondrial complexes that contain VDAC1, VDAC2, VDAC3 and BAX or BAK.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Embryonic Fibroblast, Embryonic Fibroblast Cell Line

SUBMITTER: Laura Dagley  

LAB HEAD: Grant Dewson

PROVIDER: PXD011195 | Pride | 2018-10-29

REPOSITORIES: Pride