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Streptococcus agalactiae LC-MSMS

ABSTRACT: The human-derived serotype Ⅴ ST1 GBS strains NNA038 and NNA048 was isolated from a amniotic fluid of full-term pregnant woman who suffered from premature rupture of membrane in China.Serotype Ia ST7 GBS strain YM001 is an attenuated strain ,its parent strain HN016 was isolated from an outbreak epidemical disease in tilapia from China.HN016_KO_D2 is a knockout strain from Serotype Ia ST7 GBS strain HN016.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Streptococcus Agalactiae

TISSUE(S): Whole Body

SUBMITTER: ming chen

LAB HEAD: Ming Chen

PROVIDER: PXD011206 | Pride | 2019-11-12

REPOSITORIES: Pride

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Comparative multi-omics systems analysis reveal the glycolysis / gluconeogenesis signal pathway play an important role in virulence attenuation in fish-derived GBS YM001.

Liu Yu Y Li Liping L Huang Ting T Wang Rui R Liang Wanwen W Yang Qiong Q Lei Aiying A Chen Ming M

PloS one 20190826 8

Streptococcus agalactiae(GBS) is a seriously threat to the farmed tilapia, and oral vaccination was considered to be the most desirable means which requires deep understanding of virulence mechanism of the fish-derived GBS. Our previous genome study of the fish-derived attenuated strain YM001 showed that there were two large deletions in YM001 compared to its parental virulent strain HN016. In this study, a combined transcriptomic and proteomic analysis was performed on YM001 and HN016 strains, ...[more]

PMID: 31449567

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