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Potato ATG8 interactome - N-terminal β-strand underpins biochemical specialization of an ATG8 isoform

ABSTRACT: GFP-IP based interactome of potato ATG8 isoforms following transient expression in Nicotiana benthamiana.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Nicotiana Benthamiana

TISSUE(S): Leaf

SUBMITTER: Richard Imre

LAB HEAD: Yasin Dagdas

PROVIDER: PXD011226 | Pride | 2019-11-12

REPOSITORIES: Pride

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N-terminal β-strand underpins biochemical specialization of an ATG8 isoform.

Zess Erin K EK Jensen Cassandra C Cruz-Mireles Neftaly N De la Concepcion Juan Carlos JC Sklenar Jan J Stephani Madlen M Imre Richard R Roitinger Elisabeth E Hughes Richard R Belhaj Khaoula K Mechtler Karl K Menke Frank L H FLH Bozkurt Tolga T Banfield Mark J MJ Kamoun Sophien S Maqbool Abbas A Dagdas Yasin F YF

PLoS biology 20190722 7

Autophagy-related protein 8 (ATG8) is a highly conserved ubiquitin-like protein that modulates autophagy pathways by binding autophagic membranes and a number of proteins, including cargo receptors and core autophagy components. Throughout plant evolution, ATG8 has expanded from a single protein in algae to multiple isoforms in higher plants. However, the degree to which ATG8 isoforms have functionally specialized to bind distinct proteins remains unclear. Here, we describe a comprehensive prote ...[more]

PMID: 31329577

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