Dataset Information
Exosomes of p53 mutant H1299 cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung, Epithelial Cell
DISEASE(S): Non-small Cell Lung Carcinoma
SUBMITTER: 
Sara Zanivan
LAB HEAD: Sara Zanivan
PROVIDER: PXD011241 | Pride | 2018-12-04
REPOSITORIES: Pride
Publications
Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels.
Nature communications 20181129 1
Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercellular transfer of mutp53's invasive/migratory gain-of-function by increasing RCP-dependent integrin recycling in other tumour cells. This process depends on mutp53's ability to control production of the sialomucin, podocalyxin, and activity of the Rab3 ...[more]
