Dataset Information


Exosomes of p53 mutant H1299 cells

ABSTRACT: Proteome of exosomes purified from H1299-p53R273H (mutant) and H1299-p53-/- cells, which found the levels of Podocalyxin altered in p53-mutant cells.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo sapiens  


DISEASE(S): Non-small Cell Lung Carcinoma

SUBMITTER: Sara Zanivan  

LAB HEAD: Sara Zanivan

PROVIDER: PXD011241 | Pride | 2018-12-04


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Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercellular transfer of mutp53's invasive/migratory gain-of-function by increasing RCP-dependent integrin recycling in other tumour cells. This process depends on mutp53's ability to control production of the sialomucin, podocalyxin, and activity of the Rab3  ...[more]

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