Name: Analysis of YAP1 phosphorylation sites induced by TAK1
Keywords: Human

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Analysis of YAP1 phosphorylation sites induced by TAK1

ABSTRACT: This study aims at determining which YAP residues are phosphorylated by TAK1.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Wounds And Injuries

SUBMITTER: Yujie Deng

LAB HEAD: Hai Song

PROVIDER: PXD011256 | Pride | 2018-11-04

REPOSITORIES: Pride

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Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation.

Deng Yujie Y Lu Jinqiu J Li Wenling W Wu Ailing A Zhang Xu X Tong Wenxue W Ho Kiwai Kevin KK Qin Ling L Song Hai H Mak Kinglun Kingston KK

Nature communications 20181101 1

Osteoarthritis is one of the leading causes of pain and disability in the aged population due to articular cartilage damage. This warrants investigation of signaling mechanisms that could protect cartilage from degeneration and degradation. Here we show in a murine model of experimental osteoarthritis that YAP activation by transgenic overexpression or by deletion of its upstream inhibitory kinases Mst1/2 preserves articular cartilage integrity, whereas deletion of YAP in chondrocytes promotes c ...[more]

PMID: 30385786

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