Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Erythrocyte, Blood Cell, Blood Plasma, Blood
SUBMITTER: Johan Palmfeldt
LAB HEAD: Johan Palmfeldt
PROVIDER: PXD011314 | Pride | 2019-07-31
REPOSITORIES: Pride
ACS chemical biology 20181203 12
Methylglyoxal (MG) is quantitatively the most important precursor to advanced glycation end-products (AGEs), and evidence is accumulating that it is also a causally linked to diabetes and aging related diseases. Living systems primarily reside on the glyoxalase system to detoxify MG into benign d-lactate. The flux to either glycation or detoxification, accordingly, is a key parameter for how well a system handles the ubiquitous glyoxal burden. Furthermore, insight into proteins and in particular ...[more]