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Glomerular and tubule OST48 Podocin-Cre SWATH

ABSTRACT: Enrichment of glomeruli and tubules from kidneys of OST48 Podicin-Cre mice, analysed by SWATH-MS

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Kidney

SUBMITTER: Benjamin Schulz

LAB HEAD: Benjamin Luke Schulz

PROVIDER: PXD011434 | Pride | 2021-07-26

REPOSITORIES: Pride

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The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition).

Zhuang Aowen A Yap Felicia Y T FYT Borg Danielle J DJ McCarthy Domenica D Fotheringham Amelia A Leung Sherman S Penfold Sally A SA Sourris Karly C KC Coughlan Melinda T MT Schulz Benjamin L BL Forbes Josephine M JM

Endocrinology, diabetes & metabolism 20210622 3

<h4>Aims</h4>The accumulation of advanced glycation end products is implicated in the development and progression of diabetic kidney disease. No study has examined whether stimulating advanced glycation clearance via receptor manipulation is reno-protective in diabetes. Podocytes, which are early contributors to diabetic kidney disease and could be a target for reno-protection.<h4>Materials and methods</h4>To examine the effects of increased podocyte oligosaccharyltransferase-48 on kidney functi ...[more]

PMID: 34277994

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